Role of inflammatory mediators (TNF-α, IL-6, CRP), biochemical and hematological parameters in type 2 diabetes mellitus patients of Kashmir, India

↑What is "already known" in this topic: Effect of the pro and anti-inflammatory cytokines like (TNF-α, IL-6, CRP) has been reported in insulin signaling pathways, cross-linking and ultimately developing insulin resistance in β-cells of pancreas which further risks to T2DM.Stability among these Pro and anti-inflammatory cytokines is necessary to make β-cells immune to any infection which may lead to T2DM.→What this article adds: Our experimental findings provide evidence that the pattern and variation of these cytokines (TNF-α, IL-6, CRP, and WBC) are important in the pathogenesis of T2DM.The significant correlation of these inflammatory mediators in T2DM cases with glycemic profile and insulin sensitivity leads to the pathogenesis of diseases in this ethnic population.These findings confirms that TNF-α, IL-6, plays a positive role in the pathogenesis of T2DM in this ethnic population of Kashmir and can act as an early prediction biomarkers.