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Rapamycin, anti-aging, and avoiding the fate of Tithonus

Arlan Richardson

Journal of Clinical Investigation · 2013 · ▲ 32 citations

Abstract

The discovery that mTOR(definition)-inhibiting drug studied for extending healthspan and lifespan." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">rapamycin(definition) increased the lifespan of mice was recognized by Science as one of the top 10 scientific breakthroughs of 2009. In addition to increasing lifespan, Neff and colleagues show that while rapamycin improves several functions/pathologies that change with age, it has little effect on the majority of the physiological and structural parameters they evaluated. What do these data tell us about the ability of rapamycin to delay aging and improve quality of life, i.e., prevent the fate of Tithonus?

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Provenance

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OpenAlex
DOI
10.1172/jci70800
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2026-06-13 MST

Cite this

APA
Richardson, A. (2013). Rapamycin, anti-aging, and avoiding the fate of Tithonus. <em>Journal of Clinical Investigation</em>. https://doi.org/10.1172/jci70800
Vancouver
Richardson A. Rapamycin, anti-aging, and avoiding the fate of Tithonus. Journal of Clinical Investigation. 2013. doi:10.1172/jci70800.
BibTeX
@article{arlan2013Rapamy, title = {Rapamycin, anti-aging, and avoiding the fate of Tithonus}, author = {Arlan Richardson}, journal = {Journal of Clinical Investigation}, year = {2013}, doi = {10.1172/jci70800}, }

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