Citation only via Europe PMC

Predicting healthspan and disease risks through biological age.

Li G, Cheng L, Wong IN, Yin Y, Chen J, Liu L, Zhang K.

Trends in molecular medicine · 2026 · ▲ 1 citations

Telomere attrition Cellular senescence

Abstract

Aging is the gradual decline in physiological function essential for survival and reproduction. Unlike age-associated diseases, aging affects all individuals within a species, causing progressive impairments across multiple systems. Research shows that altering specific genes or dietary factors can extend lifespan, implicating molecular pathways in controlling senescence. Chronological age (CA) is a common measure of aging, but other hallmarks like telomere shortening better quantify functional decline. Identifying age-related hallmarks can help manipulate aging, spurring interest in aging clocks. These clocks predict biological age (BA) more precisely than CA, reflecting actual physiological health. As global life expectancy continues to rise, aging clocks hold promise for developing therapies to extend healthspan and improve life quality during aging.

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Provenance

Source: Europe PMC
DOI: 10.1016/j.molmed.2025.10.006
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Fetched: 2026-05-31 MST

Cite this

APA

G, L., L, C., IN, W., Y, Y., J, C., L, L., & K., Z. (2026). Predicting healthspan and disease risks through biological age. <em>Trends in molecular medicine</em>. https://doi.org/10.1016/j.molmed.2025.10.006

Vancouver

G L, L C, IN W, Y Y, J C, L L, et al. Predicting healthspan and disease risks through biological age. Trends in molecular medicine. 2026. doi:10.1016/j.molmed.2025.10.006.

BibTeX

@article{li2026Predic, title = {Predicting healthspan and disease risks through biological age.}, author = {Li G and Cheng L and Wong IN and Yin Y and Chen J and Liu L and Zhang K.}, journal = {Trends in molecular medicine}, year = {2026}, doi = {10.1016/j.molmed.2025.10.006}, }