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Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway

Tao Chen, Siyuan Luo, Xiaoju Wang, Yiling Zhou, Yali Dai, Lijun Zhou, Shiling Feng, Ming Yuan, Chunbang Ding

Antioxidants · 2021 · ▲ 17 citations

Deregulated nutrient-sensing Mitochondrial dysfunction Altered intercellular communication Cell culture / in vitro C. elegans In vitro

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Abstract

Blumea laciniata is widely used as a folk medicine in Asia, but relevant literature on it is rarely reported. We confirmed that polyphenol extract (containing chlorogenic acid, rutin, and luteolin-4-O-glucoside) from B. laciniata (EBL) showed strong antioxidant ability in vitro. Hence, in this work, we applied Caenorhabditis elegans to further investigate the antioxidant and anti-ageing abilities of EBL in vivo. The results showed that EBL enhanced the survival of C. elegans under thermal stress by 12.62% and sharply reduced the reactive oxygen species level as well as the content of malonaldehyde. Moreover, EBL increased the activities of antioxidant enzymes such as catalase and superoxide dismutase. Additionally, EBL promoted DAF-16, a transcription factor, into the nucleus. Besides, EBL extended the lifespan of C. elegans by 17.39%, showing an anti-ageing effect. Different mutants indicated that the insulin/IGF-1 signaling pathway participated in the antioxidant and anti-ageing effect of EBL on C. elegans.

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Provenance

Source: OpenAlex
DOI: 10.3390/antiox10111744
Canonical: link ↗
Fetched: 2026-10-12 MST

Cite this

APA

Chen, T., Luo, S., Wang, X., Zhou, Y., Dai, Y., Zhou, L., Feng, S., Yuan, M., & Ding, C. (2021). Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway. <em>Antioxidants</em>. https://doi.org/10.3390/antiox10111744

Vancouver

Chen T, Luo S, Wang X, Zhou Y, Dai Y, Zhou L, et al. Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway. Antioxidants. 2021. doi:10.3390/antiox10111744.

BibTeX

@article{tao2021Polyph, title = {Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway}, author = {Tao Chen and Siyuan Luo and Xiaoju Wang and Yiling Zhou and Yali Dai and Lijun Zhou and Shiling Feng and Ming Yuan and Chunbang Ding}, journal = {Antioxidants}, year = {2021}, doi = {10.3390/antiox10111744}, }