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Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster

Aging · 2011 · ▲ 59 citations

Chronic inflammation Drosophila

Abstract

Aging is associated with NF-κB-dependent pro-inflammation. Here we demonstrated that inhibition of NF-κB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.100314
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Fetched: 2026-06-30 MST

Cite this

APA

Moskalev, A., & Shaposhnikov, M. (2011). Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster. <em>Aging</em>. https://doi.org/10.18632/aging.100314

Vancouver

Moskalev A, Shaposhnikov M. Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster. Aging. 2011. doi:10.18632/aging.100314.

BibTeX

@article{alexey2011Pharma, title = {Pharmacological inhibition of NF-κB prolongs lifespan of Drosophila melanogaster}, author = {Alexey Moskalev and Mikhail Shaposhnikov}, journal = {Aging}, year = {2011}, doi = {10.18632/aging.100314}, }