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Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling

Weitong Xu, Tingting Zhao, Honghan Chen, Ning Huang, Hui Gong, Jian Zhang, Yang Yu, Tiepeng Li, Gongchang Zhang, Chuhui Gong, Ming Yang, Hengyi Xiao

Biochemical Pharmacology · 2022 · ▲ 17 citations

Deregulated nutrient-sensing Cellular senescence Altered intercellular communication Senolytics Rapamycin / mTOR inhibition

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Provenance

Source: OpenAlex
DOI: 10.1016/j.bcp.2022.115045
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Fetched: 2026-07-19 MST

Cite this

APA

Xu, W., Zhao, T., Chen, H., Huang, N., Gong, H., Zhang, J., Yu, Y., Li, T., Zhang, G., Gong, C., Yang, M., & Xiao, H. (2022). Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling. <em>Biochemical Pharmacology</em>. https://doi.org/10.1016/j.bcp.2022.115045

Vancouver

Xu W, Zhao T, Chen H, Huang N, Gong H, Zhang J, et al. Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling. Biochemical Pharmacology. 2022. doi:10.1016/j.bcp.2022.115045.

BibTeX

@article{weitong2022PanmTO, title = {Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling}, author = {Weitong Xu and Tingting Zhao and Honghan Chen and Ning Huang and Hui Gong and Jian Zhang and Yang Yu and Tiepeng Li and Gongchang Zhang and Chuhui Gong and Ming Yang and Hengyi Xiao}, journal = {Biochemical Pharmacology}, year = {2022}, doi = {10.1016/j.bcp.2022.115045}, }