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NAD+ metabolism-based immunoregulation and therapeutic potential

Jiankai Fang, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo, Shisong Liu, Chao Feng, Yuyi Han, Peishan Li, Yufang Shi, Changshun Shao

Cell & Bioscience · 2023 · ▲ 41 citations

Deregulated nutrient-sensing Chronic inflammation Review
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Abstract

Abstract Nicotinamide adenine dinucleotide (NAD + ) is a critical metabolite that acts as a cofactor in energy metabolism, and serves as a cosubstrate for non-redox NAD + -dependent enzymes, including sirtuins, CD38 and poly(ADP-ribose) polymerases. NAD + metabolism can regulate functionality attributes of innate and adaptive immune cells and contribute to inflammatory responses. Thus, the manipulation of NAD + bioavailability can reshape the courses of immunological diseases. Here, we review the basics of NAD + biochemistry and its roles in the immune response, and discuss current challenges and the future translational potential of NAD + research in the development of therapeutics for inflammatory diseases, such as COVID-19.

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Provenance

Source
OpenAlex
DOI
10.1186/s13578-023-01031-5
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Fetched
2026-06-16 MST

Cite this

APA
Fang, J., Chen, W., Hou, P., Liu, Z., Zuo, M., Liu, S., Feng, C., Han, Y., Li, P., Shi, Y., &amp; Shao, C. (2023). NAD+ metabolism-based immunoregulation and therapeutic potential. <em>Cell & Bioscience</em>. https://doi.org/10.1186/s13578-023-01031-5
Vancouver
Fang J, Chen W, Hou P, Liu Z, Zuo M, Liu S, et al. NAD+ metabolism-based immunoregulation and therapeutic potential. Cell & Bioscience. 2023. doi:10.1186/s13578-023-01031-5.
BibTeX
@article{jiankai2023NADmet, title = {NAD+ metabolism-based immunoregulation and therapeutic potential}, author = {Jiankai Fang and Wangwang Chen and Pengbo Hou and Zhanhong Liu and Muqiu Zuo and Shisong Liu and Chao Feng and Yuyi Han and Peishan Li and Yufang Shi and Changshun Shao}, journal = {Cell & Bioscience}, year = {2023}, doi = {10.1186/s13578-023-01031-5}, }

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