Preprint · OA via OpenAlex

NAD+ as a Signaling Molecule Modulating Metabolism

Cold Spring Harbor Symposia on Quantitative Biology · 2011 · ▲ 106 citations

Deregulated nutrient-sensing Altered intercellular communication

Abstract

The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1101/sqb.2012.76.010439
Canonical: link ↗
Fetched: 2026-07-20 MST

Cite this

APA

Cantó, C., & Auwerx, J. (2011). NAD+ as a Signaling Molecule Modulating Metabolism. <em>Cold Spring Harbor Symposia on Quantitative Biology</em>. https://doi.org/10.1101/sqb.2012.76.010439

Vancouver

Cantó C, Auwerx J. NAD+ as a Signaling Molecule Modulating Metabolism. Cold Spring Harbor Symposia on Quantitative Biology. 2011. doi:10.1101/sqb.2012.76.010439.

BibTeX

@unpublished{carles2011NADasa, title = {NAD+ as a Signaling Molecule Modulating Metabolism}, author = {Carles Cantó and Johan Auwerx}, journal = {Cold Spring Harbor Symposia on Quantitative Biology}, year = {2011}, doi = {10.1101/sqb.2012.76.010439}, }