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Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease

Sofie Lautrup, Guofeng Lou, Yahyah Aman, Hilde Nilsen, Jun Tao, Evandro Fei Fang

Neurochemistry International · 2019 · ▲ 103 citations

Mitochondrial dysfunction Chronic inflammation Disabled macroautophagy

Abstract

In neurons, defective mitophagy results in accumulation of damaged mitochondria, and finally leading to various neurodegenerative diseases, including Alzheimer's disease (AD). However, how mitophagy is defective in AD as well as how defective mitophagy contributes to AD is not fully understood. We give commentary on recent progress of this topic, highlighting the importance of mitophagy not only in neurons, but also in microglia, in forestalling pathology and cognitive decline in different animal models of AD.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.neuint.2019.104469
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Fetched: 2026-08-03 MST

Cite this

APA

Lautrup, S., Lou, G., Aman, Y., Nilsen, H., Tao, J., & Fang, E.F. (2019). Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease. <em>Neurochemistry International</em>. https://doi.org/10.1016/j.neuint.2019.104469

Vancouver

Lautrup S, Lou G, Aman Y, Nilsen H, Tao J, Fang EF. Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease. Neurochemistry International. 2019. doi:10.1016/j.neuint.2019.104469.

BibTeX

@article{sofie2019Microg, title = {Microglial mitophagy mitigates neuroinflammation in Alzheimer's disease}, author = {Sofie Lautrup and Guofeng Lou and Yahyah Aman and Hilde Nilsen and Jun Tao and Evandro Fei Fang}, journal = {Neurochemistry International}, year = {2019}, doi = {10.1016/j.neuint.2019.104469}, }