Open access · CC-BY via OpenAlex

Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review

Ιoannis Ilias, Manfredi Rizzo, Lina Zabulienė

Medicina · 2022 · ▲ 31 citations

Deregulated nutrient-sensing Metformin Review

Abstract

Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.3390/medicina58030430
Canonical: link ↗
Fetched: 2026-10-09 MST

Cite this

APA

Ilias, �., Rizzo, M., & Zabulienė, L. (2022). Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review. <em>Medicina</em>. https://doi.org/10.3390/medicina58030430

Vancouver

Ilias �, Rizzo M, Zabulienė L. Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review. Medicina. 2022. doi:10.3390/medicina58030430.

BibTeX

@article{oannis2022Metfor, title = {Metformin: Sex/Gender Differences in Its Uses and Effects—Narrative Review}, author = {Ιoannis Ilias and Manfredi Rizzo and Lina Zabulienė}, journal = {Medicina}, year = {2022}, doi = {10.3390/medicina58030430}, }