Metabolic Disequilibrium and Aging: Modifying Favorably with Calorie Restriction and Calorie Restriction Mimetics

Metabolic Disequilibrium and DisordersThere is increasing evidence that metabolic disequilibrium and disorders impact general health, aging process and survival including the quality of life (QOL).There is a changing pattern of diseases caused by overnutrition and unhealthy lifestyle.With weight gain and obesity, the adipose tissue mediates various metabolic disorders such as insulin resistance (IR), metabolic syndrome (MetS), dyslipidemia and type 2 diabetes mellitus (T2DM), altogether which negatively affect the lifespan and disfavorably modify the aging process in various tissues and organs through a number of metabolic pathways. Metabolic disorders and aging processAs proved by various studies, the metabolic disorders are closely related with aging process.The development of IR is one of the most important risk factors for metabolic Crimson