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Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care

Nicolas J. Pillon, Ruth J. F. Loos, Sally M. Marshall, Juleen Rae Zierath

Cell · 2021 · ▲ 237 citations

Chronic inflammation Human Review

Abstract

The prevalence of type 2 diabetes and obesity has risen dramatically for decades and is expected to rise further, secondary to the growing aging, sedentary population. The strain on global health care is projected to be colossal. This review explores the latest work and emerging ideas related to genetic and environmental factors influencing metabolism. Translational research and clinical applications, including the impact of the COVID-19 pandemic, are highlighted. Looking forward, strategies to personalize all aspects of prevention, management and care are necessary to improve health outcomes and reduce the impact of these metabolic diseases.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.cell.2021.02.012
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Fetched: 2026-09-24 MST

Cite this

APA

Pillon, N.J., Loos, R.J.F., Marshall, S.M., & Zierath, J.R. (2021). Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care. <em>Cell</em>. https://doi.org/10.1016/j.cell.2021.02.012

Vancouver

Pillon NJ, Loos RJF, Marshall SM, Zierath JR. Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care. Cell. 2021. doi:10.1016/j.cell.2021.02.012.

BibTeX

@article{nicolas2021Metabo, title = {Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care}, author = {Nicolas J. Pillon and Ruth J. F. Loos and Sally M. Marshall and Juleen Rae Zierath}, journal = {Cell}, year = {2021}, doi = {10.1016/j.cell.2021.02.012}, }