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Metabolomic-based aging clocks

Alain Ibáñez de Opakua, Ricardo Conde, Ángela de Diego, Maider Bizkarguenaga, Nieves Embade, Shelly C. Lu, José M. Mato, Óscar Millet

npj Metabolic Health and Disease · 2025 · ▲ 6 citations

Epigenetic alterations Human

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Abstract

Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolomic clocks provide a non-invasive, high-throughput platform to assess metabolic health. We summarize key NMR-based models and present a new approach that combines high predictive accuracy with clinical interpretability, identifying disease-specific metabolic distortions and supporting risk stratification and early detection of accelerated aging.

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Provenance

Source: OpenAlex
DOI: 10.1038/s44324-025-00078-x
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Fetched: 2026-07-28 MST

Cite this

APA

Opakua, A.I.D., Conde, R., Diego, �.D., Bizkarguenaga, M., Embade, N., Lu, S.C., Mato, J.M., & Millet, �. (2025). Metabolomic-based aging clocks. <em>npj Metabolic Health and Disease</em>. https://doi.org/10.1038/s44324-025-00078-x

Vancouver

Opakua AID, Conde R, Diego �D, Bizkarguenaga M, Embade N, Lu SC, et al. Metabolomic-based aging clocks. npj Metabolic Health and Disease. 2025. doi:10.1038/s44324-025-00078-x.

BibTeX

@article{alain2025Metabo, title = {Metabolomic-based aging clocks}, author = {Alain Ibáñez de Opakua and Ricardo Conde and Ángela de Diego and Maider Bizkarguenaga and Nieves Embade and Shelly C. Lu and José M. Mato and Óscar Millet}, journal = {npj Metabolic Health and Disease}, year = {2025}, doi = {10.1038/s44324-025-00078-x}, }