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Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling

Jéssika Cristina Bridi, Alexandre Guimarães de Almeida Barros, Letícia Reis Sampaio, Júlia Castro Damásio Ferreira, Félix Alexandre Antunes Soares, Marco Aurélio Romano‐Silva

Frontiers in Aging Neuroscience · 2015 · ▲ 47 citations

Deregulated nutrient-sensing Altered intercellular communication C. elegans
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Abstract

Caffeine is a widely used psychoactive substance. Studies have shown that caffeine may play a protective role in aging-associated disorders. However, the mechanisms by which caffeine modulates aging are not yet clear. In this study, we have shown that caffeine increases Caenorhabditis elegans lifespan, delays its larval development, reduces reproduction and body length. These phenotypes were partly reversed by worm's exposure to adenosine, which suggest a putative common target. Moreover, they were dependent on a functional insulin/IGF-1-like pathway. Our results may shed light on new genetic determinants of aging.

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Provenance

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OpenAlex
DOI
10.3389/fnagi.2015.00220
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2026-06-15 MST

Cite this

APA
Bridi, J.C., Barros, A.G.D.A., Sampaio, L.R., Ferreira, J.C.D., Soares, F.A.A., &amp; Romano‐Silva, M.A. (2015). Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling. <em>Frontiers in Aging Neuroscience</em>. https://doi.org/10.3389/fnagi.2015.00220
Vancouver
Bridi JC, Barros AGDA, Sampaio LR, Ferreira JCD, Soares FAA, Romano‐Silva MA. Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling. Frontiers in Aging Neuroscience. 2015. doi:10.3389/fnagi.2015.00220.
BibTeX
@article{jssika2015Lifesp, title = {Lifespan Extension Induced by Caffeine in Caenorhabditis elegans is Partially Dependent on Adenosine Signaling}, author = {Jéssika Cristina Bridi and Alexandre Guimarães de Almeida Barros and Letícia Reis Sampaio and Júlia Castro Damásio Ferreira and Félix Alexandre Antunes Soares and Marco Aurélio Romano‐Silva}, journal = {Frontiers in Aging Neuroscience}, year = {2015}, doi = {10.3389/fnagi.2015.00220}, }

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