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Integration of diverse inputs in the regulation of <i>Caenorhabditis elegans</i> DAF‐16/FOXO

J. Landis, Coleen T. Murphy

Developmental Dynamics · 2010 · ▲ 86 citations

Deregulated nutrient-sensing Altered intercellular communication C. elegans Review
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Abstract

In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.

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Provenance

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OpenAlex
DOI
10.1002/dvdy.22244
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2026-06-30 MST

Cite this

APA
Landis, J., &amp; Murphy, C.T. (2010). Integration of diverse inputs in the regulation of <i>Caenorhabditis elegans</i> DAF‐16/FOXO. <em>Developmental Dynamics</em>. https://doi.org/10.1002/dvdy.22244
Vancouver
Landis J, Murphy CT. Integration of diverse inputs in the regulation of <i>Caenorhabditis elegans</i> DAF‐16/FOXO. Developmental Dynamics. 2010. doi:10.1002/dvdy.22244.
BibTeX
@article{j2010Integr, title = {Integration of diverse inputs in the regulation of <i>Caenorhabditis elegans</i> DAF‐16/FOXO}, author = {J. Landis and Coleen T. Murphy}, journal = {Developmental Dynamics}, year = {2010}, doi = {10.1002/dvdy.22244}, }

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