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Inflammation and Aging of Hematopoietic Stem Cells in Their Niche

Cells · 2021 · ▲ 55 citations

Stem-cell exhaustion Chronic inflammation Cell culture / in vitro Review

Abstract

Hematopoietic stem cells (HSCs) sustain the lifelong production of all blood cell lineages. The functioning of aged HSCs is impaired, including a declined repopulation capacity and myeloid and platelet-restricted differentiation. Both cell-intrinsic and microenvironmental extrinsic factors contribute to HSC aging. Recent studies highlight the emerging role of inflammation in contributing to HSC aging. In this review, we summarize the recent finding of age-associated changes of HSCs and the bone marrow niche in which they lodge, and discuss how inflammation may drive HSC aging.

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Provenance

Source: OpenAlex
DOI: 10.3390/cells10081849
Canonical: link ↗
Fetched: 2026-09-27 MST

Cite this

APA

Yang, D., & Haan, G.D. (2021). Inflammation and Aging of Hematopoietic Stem Cells in Their Niche. <em>Cells</em>. https://doi.org/10.3390/cells10081849

Vancouver

Yang D, Haan GD. Inflammation and Aging of Hematopoietic Stem Cells in Their Niche. Cells. 2021. doi:10.3390/cells10081849.

BibTeX

@article{daozheng2021Inflam, title = {Inflammation and Aging of Hematopoietic Stem Cells in Their Niche}, author = {Daozheng Yang and Gerald de Haan}, journal = {Cells}, year = {2021}, doi = {10.3390/cells10081849}, }