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In vivo neuron-specific expression of C. elegans reprogramming factor orthologs does not alleviate age-related cognitive decline

Erik Toraason, Rachel Kaletsky, Coleen T. Murphy

PubMed · 2024 · ▲ 1 citations

Deregulated nutrient-sensing Partial reprogramming (OSK) C. elegans

Abstract

neurons. We find that OSK does not improve short-term associative memory or extend lifespan and can further disrupt chemotaxis behavior. Taken together, our data suggest that OSK-mediated partial reprogramming may have deleterious effects on post-mitotic neurons that function in cognitive processes.

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Provenance

Source: OpenAlex
DOI: 10.17912/micropub.biology.001304
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Fetched: 2026-06-19 MST

Cite this

APA

Toraason, E., Kaletsky, R., & Murphy, C.T. (2024). In vivo neuron-specific expression of C. elegans reprogramming factor orthologs does not alleviate age-related cognitive decline. <em>PubMed</em>. https://doi.org/10.17912/micropub.biology.001304

Vancouver

Toraason E, Kaletsky R, Murphy CT. In vivo neuron-specific expression of C. elegans reprogramming factor orthologs does not alleviate age-related cognitive decline. PubMed. 2024. doi:10.17912/micropub.biology.001304.

BibTeX

@unpublished{erik2024Invivo, title = {In vivo neuron-specific expression of C. elegans reprogramming factor orthologs does not alleviate age-related cognitive decline}, author = {Erik Toraason and Rachel Kaletsky and Coleen T. Murphy}, journal = {PubMed}, year = {2024}, doi = {10.17912/micropub.biology.001304}, }