Open access · OA via OpenAlex

IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin

Satoshi Horiba, Ryota Kami, Taiki Tsutsui, Junichi Hosoi

JID Innovations · 2022 · ▲ 33 citations

Chronic inflammation Cell culture / in vitro Human In vitro

Abstract

cells was decreased in aged skin and negatively correlated with the M1-to-M2 ratio. Furthermore, IL-34 induced the expression of CD206 and IL-10, which are M2 macrophage markers, in an in vitro assay. Our results suggest that a reduction in epidermal IL-34 in aged skin may skew the M1/M2 balance in the dermis and lead to low-grade chronic inflammation and inflammaging.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1016/j.xjidi.2022.100112
Canonical: link ↗
Fetched: 2026-06-08 MST

Cite this

APA

Horiba, S., Kami, R., Tsutsui, T., & Hosoi, J. (2022). IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin. <em>JID Innovations</em>. https://doi.org/10.1016/j.xjidi.2022.100112

Vancouver

Horiba S, Kami R, Tsutsui T, Hosoi J. IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin. JID Innovations. 2022. doi:10.1016/j.xjidi.2022.100112.

BibTeX

@article{satoshi2022ILDown, title = {IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin}, author = {Satoshi Horiba and Ryota Kami and Taiki Tsutsui and Junichi Hosoi}, journal = {JID Innovations}, year = {2022}, doi = {10.1016/j.xjidi.2022.100112}, }