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Human cancer, the naked mole rat and faunal turnovers

Cancer Medicine · 2019 · ▲ 6 citations

Deregulated nutrient-sensing Rat Human Naked mole-rat

Abstract

We argue that the human evolutionary heritage with frequent adaptations through geological time to environmental change has affected a trade-off between offspring variability and cancer resistance, and thus favored cancer-prone individuals. We turn the attention to a factor setting the highly cancer-resistant naked mole rat apart from most other mammals: it has remained phenotypically largely unchanged since 30-50 million years ago. Research focusing on DNA stability mechanisms in 'living fossil' animals may help us find tools for cancer prevention and treatment.

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Provenance

Source: OpenAlex
DOI: 10.1002/cam4.2011
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Fetched: 2026-07-07 MST

Cite this

APA

Bredberg, A., & Schmitz, B. (2019). Human cancer, the naked mole rat and faunal turnovers. <em>Cancer Medicine</em>. https://doi.org/10.1002/cam4.2011

Vancouver

Bredberg A, Schmitz B. Human cancer, the naked mole rat and faunal turnovers. Cancer Medicine. 2019. doi:10.1002/cam4.2011.

BibTeX

@article{anders2019Humanc, title = {Human cancer, the naked mole rat and faunal turnovers}, author = {Anders Bredberg and Birger Schmitz}, journal = {Cancer Medicine}, year = {2019}, doi = {10.1002/cam4.2011}, }