Naked mole-rat

High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

The mouse-sized naked mole rat (Heterocephalus glaber) is a very unusual mammal. It is a social animal, living in groups in burrows beneath arid African deserts. It can live for 30 or more years in atmospheres with low oxygen and high carbo...

Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat

The naked mole-rat is the longest living rodent with a maximum lifespan exceeding 28 years. In addition to its longevity, naked mole-rats have an extraordinary resistance to cancer as tumors have never been observed in these rodents. Furthe...

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-rel...

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/protea...

DNA repair in species with extreme lifespan differences

Differences in DNA repair capacity have been hypothesized to underlie the great range of maximum lifespans among mammals. However, measurements of individual DNA repair activities in cells and animals have not substantiated such a relations...

Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism

Blind mole rats Spalax (BMR) are small subterranean rodents common in the Middle East. BMR is distinguished by its adaptations to life underground, remarkable longevity (with a maximum documented lifespan of 21 y), and resistance to cancer....

Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage

The naked mole-rat (Heterocephalus glaber) is a subterranean eusocial rodent with a markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation of protein translation in longevity. Here we report that 28S ribo...

Being cool: how body temperature influences ageing and longevity

Temperature is a basic and essential property of any physical system, including living systems. Even modest variations in temperature can have profound effects on organisms, and it has long been thought that as metabolism increases at highe...

Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice

Alternative Animal Models of Aging Research

Most research on mechanisms of aging is being conducted in a very limited number of classical model species, i.e., laboratory mouse ( Mus musculus ), rat ( Rattus norvegicus domestica ), the common fruit fly ( Drosophila melanogaster ) and...

Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity

The immune system comprises a complex network of specialized cells that protects against infection, eliminates cancerous cells, and regulates tissue repair, thus serving a critical role in homeostasis, health span, and life span. The subter...