Model organism
Naked mole-rat
- Works
- 340
- Most cited
- 815
Most-cited works
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
This 2013 Nature study examines the role of high-molecular-mass hyaluronan in the unique cancer resistance observed in naked mole rats.
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
The mouse-sized naked mole rat (Heterocephalus glaber) is a very unusual mammal. It is a social animal, living in groups in burrows beneath arid African deserts. It can live for 30 or more years in atmospheres with low oxygen and high carbo...
The Naked Mole-Rat: A New Long-Living Model for Human Aging Research
Tremendous variation in maximum life span among species overshadows modest increases in longevity resulting from experimental manipulation. Few aging studies focus on long-lived mammals even though these species may expose mechanisms involv...
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat
The naked mole-rat is the longest living rodent with a maximum lifespan exceeding 28 years. In addition to its longevity, naked mole-rats have an extraordinary resistance to cancer as tumors have never been observed in these rodents. Furthe...
Naked mole-rat mortality rates defy Gompertzian laws by not increasing with age
, has a reported maximum lifespan of >30 years and exhibits delayed and/or attenuated age-associated physiological declines. We questioned whether these mouse-sized, eusocial rodents conform to Gompertzian mortality laws by experiencing an...
Regulation of Nrf2 signaling and longevity in naturally long-lived rodents
The preternaturally long-lived naked mole-rat, like other long-lived species and experimental models of extended longevity, is resistant to both endogenous (e.g., reactive oxygen species) and environmental stressors and also resists age-rel...
Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae
Aging is characterized by the accumulation of damaged cellular macromolecules caused by declining repair and elimination pathways. An integral component employed by cells to counter toxic protein aggregates is the conserved ubiquitin/protea...
Successful Aging and Sustained Good Health in the Naked Mole Rat: A Long-Lived Mammalian Model for Biogerontology and Biomedical Research
Naked mole rats (NMRs; Heterocephalus glaber) are the longest-living rodents known, with a maximum lifespan of 30 years--5 times longer than expected on the basis of body size. These highly social mouse-sized rodents, naturally found in sub...
Adaptations to a Subterranean Environment\nand Longevity Revealed by the Analysis\nof Mole Rat Genomes
Subterranean mammals spend their lives in dark,\nunventilated environments that are rich in carbon dioxide\nand ammonia and low in oxygen. Many of these\nanimals are also long-lived and exhibit reduced aging-associated\ndiseases, such as ne...
DNA repair in species with extreme lifespan differences
Differences in DNA repair capacity have been hypothesized to underlie the great range of maximum lifespans among mammals. However, measurements of individual DNA repair activities in cells and animals have not substantiated such a relations...
Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism
Blind mole rats Spalax (BMR) are small subterranean rodents common in the Middle East. BMR is distinguished by its adaptations to life underground, remarkable longevity (with a maximum documented lifespan of 21 y), and resistance to cancer....
Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage
The naked mole-rat (Heterocephalus glaber) is a subterranean eusocial rodent with a markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation of protein translation in longevity. Here we report that 28S ribo...