Citation only via OpenAlex

Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity

Mahmoud Abdellatif, Viktoria Trummer-Herbst, Heberle AM, A Humnig, Tobias Pendl, Sylvère Durand, Giulia Cerrato, Hofer SJ, M Islam, Julia Voglhuber, JM Ramos Pittol, Oliver Kepp, G Hoefler, Albrecht G. Schmidt, Rainer PP

Yearbook of pediatric endocrinology · 2022

Deregulated nutrient-sensing Altered intercellular communication Human Mouse

＋ Sign in to save

Abstract

Brief Summary: This translational study evaluated cardiac health and lifespan in two cardiomyocyte-specific transgenic mice with either enhanced or reduced IGF-1 signaling and in human cardiac biopsies from failing and nonfailing hearts. Increased IGF1R expression was related to better cardiac performance in young mice but faster decline of cardiac function with aging. Conversely reduced IGF1R signaling was associated improved lifespan and superior cardiac profile during aging. Human failing hearts showed exaggerated IGF1R signaling. These data unveil a novel role of IGF1R signaling in cardiac health, which acts in a biphasic way according to age and suggest that the use of pharmacological inhibitors of IGF1 could be beneficial in elderly adults at risk of heart failure.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1530/ey.19.4.11
Canonical: link ↗
Fetched: 2026-10-22 MST

Cite this

APA

Abdellatif, M., Trummer-Herbst, V., AM, H., Humnig, A., Pendl, T., Durand, S., Cerrato, G., SJ, H., Islam, M., Voglhuber, J., Pittol, J.R., Kepp, O., Hoefler, G., Schmidt, A.G., PP, R., Scherr, D., Lewinski, D.V., Bisping, E.H., JR, M., & Diwan, A. (2022). Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity. <em>Yearbook of pediatric endocrinology</em>. https://doi.org/10.1530/ey.19.4.11

Vancouver

Abdellatif M, Trummer-Herbst V, AM H, Humnig A, Pendl T, Durand S, et al. Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity. Yearbook of pediatric endocrinology. 2022. doi:10.1530/ey.19.4.11.

BibTeX

@article{mahmoud2022Finetu, title = {Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity}, author = {Mahmoud Abdellatif and Viktoria Trummer-Herbst and Heberle AM and A Humnig and Tobias Pendl and Sylvère Durand and Giulia Cerrato and Hofer SJ and M Islam and Julia Voglhuber and JM Ramos Pittol and Oliver Kepp and G Hoefler and Albrecht G. Schmidt and Rainer PP and D Scherr and Dirk von Lewinski and Egbert Hubertus Bisping and McMullen JR and A Diwan and Todd Eisenberg and Frank Madeo and Kathrin Thedieck and Guido Kroemer and Simon Sedej}, journal = {Yearbook of pediatric endocrinology}, year = {2022}, doi = {10.1530/ey.19.4.11}, }