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Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals

Joanna Kacprzyk, Andrea G. Locatelli, Graham M. Hughes, Zixia Huang, Michael Clarke, Vera A. Gorbunova, Carlotta Sacchi, Gavin S. Stewart, Emma C. Teeling

Aging · 2021 · ▲ 30 citations

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Abstract

, mouse), that also showed an increase with age in both bat species. Further phylogenomic selection pressure analyses across eutherian mammals (n=70 taxa; 274 genes) uncovered 10 autophagy-associated genes under selective pressure in bat lineages. These molecular adaptations potentially mediate the exceptional age-related increase of autophagy signalling in bats, which may contribute to their longer healthspans.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.202852
Canonical: link ↗
Fetched: 2026-10-22 MST

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APA

Kacprzyk, J., Locatelli, A.G., Hughes, G.M., Huang, Z., Clarke, M., Gorbunova, V.A., Sacchi, C., Stewart, G.S., & Teeling, E.C. (2021). Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals. <em>Aging</em>. https://doi.org/10.18632/aging.202852

Vancouver

Kacprzyk J, Locatelli AG, Hughes GM, Huang Z, Clarke M, Gorbunova VA, et al. Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals. Aging. 2021. doi:10.18632/aging.202852.

BibTeX

@unpublished{joanna2021Evolut, title = {Evolution of mammalian longevity: age-related increase in autophagy in bats compared to other mammals}, author = {Joanna Kacprzyk and Andrea G. Locatelli and Graham M. Hughes and Zixia Huang and Michael Clarke and Vera A. Gorbunova and Carlotta Sacchi and Gavin S. Stewart and Emma C. Teeling}, journal = {Aging}, year = {2021}, doi = {10.18632/aging.202852}, }