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Drosophila melanogaster as a model system in the study of pharmacological interventions in aging

Translational Medicine of Aging · 2019 · ▲ 45 citations

Deregulated nutrient-sensing Drosophila Review

Abstract

Drosophila melanogaster has been used as a model system in biological studies for a long time, and those studies have contributed to elucidating the principal mechanisms of life and aging. The notable advantages of Drosophila as a model system such as their low maintenance cost, high reproductive rate, and short generation time and lifespan make the flies a promising investigative platform for primary small-molecule screening of anti-aging drugs. In this review, we summarize and review the benefits of Drosophila as a model system for use in the study of pharmacological anti-aging interventions and describe the previously reported longevity effects of pharmacological interventions in Drosophila.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.tma.2019.09.004
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Fetched: 2026-06-30 MST

Cite this

APA

Lee, S., & Min, K. (2019). Drosophila melanogaster as a model system in the study of pharmacological interventions in aging. <em>Translational Medicine of Aging</em>. https://doi.org/10.1016/j.tma.2019.09.004

Vancouver

Lee S, Min K. Drosophila melanogaster as a model system in the study of pharmacological interventions in aging. Translational Medicine of Aging. 2019. doi:10.1016/j.tma.2019.09.004.

BibTeX

@article{shinhae2019Drosop, title = {Drosophila melanogaster as a model system in the study of pharmacological interventions in aging}, author = {Shin‐Hae Lee and Kyung‐Jin Min}, journal = {Translational Medicine of Aging}, year = {2019}, doi = {10.1016/j.tma.2019.09.004}, }