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DNA methylation networks underlying mammalian traits

Amin Haghani, Caesar Z. Li, Todd R. Robeck, Joshua Zhang, Ake T. Lu, Julia Ablaeva, Victoria A. Acosta-Rodríguez, Danielle M. Adams, Abdulaziz N. Alagaili, Javier Almunia, Ajoy Aloysius, Nabil Amor, Reza Ardehali, A Arneson, C. Scott Baker

Science · 2023 · ▲ 139 citations

Epigenetic alterations Caloric restriction Partial reprogramming (OSK) Telomerase activation Human

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Abstract

Using DNA methylation profiles ( n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to traits such as maximum life span, adult weight, age, sex, and human mortality risk. Maximum life span is associated with methylation levels in HOXL subclass homeobox genes and developmental processes and is potentially regulated by pluripotency transcription factors. The methylation state of some modules responds to perturbations such as caloric restriction, ablation of growth hormone receptors, consumption of high-fat diets, and expression of Yamanaka factors. This study reveals an intertwined evolution of the genome and epigenome that mediates the biological characteristics and traits of different mammalian species.

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Provenance

Source: OpenAlex
DOI: 10.1126/science.abq5693
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Fetched: 2026-09-15 MST

Cite this

APA

Haghani, A., Li, C.Z., Robeck, T.R., Zhang, J., Lu, A.T., Ablaeva, J., Acosta-Rodríguez, V.A., Adams, D.M., Alagaili, A.N., Almunia, J., Aloysius, A., Amor, N., Ardehali, R., Arneson, A., Baker, C.S., Banks, G., Belov, K., Bennett, N.C., Black, P.M., & Blumstein, D.T. (2023). DNA methylation networks underlying mammalian traits. <em>Science</em>. https://doi.org/10.1126/science.abq5693

Vancouver

Haghani A, Li CZ, Robeck TR, Zhang J, Lu AT, Ablaeva J, et al. DNA methylation networks underlying mammalian traits. Science. 2023. doi:10.1126/science.abq5693.

BibTeX

@unpublished{amin2023DNAmet, title = {DNA methylation networks underlying mammalian traits}, author = {Amin Haghani and Caesar Z. Li and Todd R. Robeck and Joshua Zhang and Ake T. Lu and Julia Ablaeva and Victoria A. Acosta-Rodríguez and Danielle M. Adams and Abdulaziz N. Alagaili and Javier Almunia and Ajoy Aloysius and Nabil Amor and Reza Ardehali and A Arneson and C. Scott Baker and Gareth Banks and Katherine Belov and Nigel C. Bennett and Peter McL. Black and Daniel T. Blumstein and Eleanor K. Bors and Charles E. Breeze and Robert T. Brooke and Janine L. Brown}, journal = {Science}, year = {2023}, doi = {10.1126/science.abq5693}, }