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Disease drivers of aging

Richard J. Hodes, Felipe Sierra, Steven N. Austad, Elissa S. Epel, Gretchen N. Neigh, Kristine M. Erlandson, Marissa Schafer, Nathan K. LeBrasseur, Christopher D. Wiley, Judith Campisi, Mary E. Sehl, Rosario Scalia, Satoru Eguchi, Balakuntalam S. Kasinath, Jeffrey B. Halter

Annals of the New York Academy of Sciences · 2016 · ▲ 130 citations

Chronic inflammation

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Abstract

It has long been known that aging, at both the cellular and organismal levels, contributes to the development and progression of the pathology of many chronic diseases. However, much less research has examined the inverse relationship-the contribution of chronic diseases and their treatments to the progression of aging-related phenotypes. Here, we discuss the impact of three chronic diseases (cancer, HIV/AIDS, and diabetes) and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging.

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Provenance

Source: OpenAlex
DOI: 10.1111/nyas.13299
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Fetched: 2026-07-27 MST

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APA

Hodes, R.J., Sierra, F., Austad, S.N., Epel, E.S., Neigh, G.N., Erlandson, K.M., Schafer, M., LeBrasseur, N.K., Wiley, C.D., Campisi, J., Sehl, M.E., Scalia, R., Eguchi, S., Kasinath, B.S., Halter, J.B., Cohen, H.J., Demark‐Wahnefried, W., Ahles, T.A., Barzilai, N., & Hurria, A. (2016). Disease drivers of aging. <em>Annals of the New York Academy of Sciences</em>. https://doi.org/10.1111/nyas.13299

Vancouver

Hodes RJ, Sierra F, Austad SN, Epel ES, Neigh GN, Erlandson KM, et al. Disease drivers of aging. Annals of the New York Academy of Sciences. 2016. doi:10.1111/nyas.13299.

BibTeX

@article{richard2016Diseas, title = {Disease drivers of aging}, author = {Richard J. Hodes and Felipe Sierra and Steven N. Austad and Elissa S. Epel and Gretchen N. Neigh and Kristine M. Erlandson and Marissa Schafer and Nathan K. LeBrasseur and Christopher D. Wiley and Judith Campisi and Mary E. Sehl and Rosario Scalia and Satoru Eguchi and Balakuntalam S. Kasinath and Jeffrey B. Halter and Harvey Jay Cohen and Wendy Demark‐Wahnefried and Tim A. Ahles and Nir Barzilai and Arti Hurria and Peter W. Hunt}, journal = {Annals of the New York Academy of Sciences}, year = {2016}, doi = {10.1111/nyas.13299}, }