Author
Nathan K. LeBrasseur
- Indexed works
- 60
- Total citations
- 22,008
- Active years
- 14
Collaborators
Works in the record
Nature 2011
Preprint · OA
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Aging Cell 2015
Open access · CC-BY
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Nature Medicine 2018
Preprint · OA
Senolytics improve physical function and increase lifespan in old age
Nature Communications 2017
Open access · CC-BY
Cellular senescence mediates fibrotic pulmonary disease
EBioMedicine 2019
Open access · CC-BY
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
EBioMedicine 2019
Open access · CC-BY
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Nature Medicine 2017
Preprint · OA
Targeting cellular senescence prevents age-related bone loss in mice
Nature Communications 2022
Open access · CC-BY
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Proceedings of the National Academy of Sciences 2015
Open access · OA
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
eLife 2015
Open access · CC-BY
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Journal of Bone and Mineral Research 2016
Preprint · OA
Identification of Senescent Cells in the Bone Microenvironment
The EMBO Journal 2019
Open access · CC-BY
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
Diabetes 2015
Preprint · OA
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
Aging Cell 2021
Open access · CC-BY
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
JCI Insight 2020
Open access · CC-BY
The senescence-associated secretome as an indicator of age and medical risk
The Annual Review of Pharmacology and Toxicology 2020
Open access · OA
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
EBioMedicine 2023
Open access · CC-BY
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability
Diabetes 2016
Preprint · OA
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
Journal of the American College of Cardiology 2021
Open access · OA
Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction
The Journals of Gerontology Series A 2009
Open access · OA
Myostatin Inhibition Enhances the Effects of Exercise on Performance and Metabolic Outcomes in Aged Mice
Nestlé Nutrition Institute Workshop series 2015
Preprint · OA
Cellular Senescence and the Biology of Aging, Disease, and Frailty
Annals of the New York Academy of Sciences 2016
Open access · OA
Disease drivers of aging
The Journals of Gerontology Series A 2016
Open access · CC-BY
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
Aging Cell 2021
Open access · CC-BY
Exercise reduces circulating biomarkers of cellular senescence in humans
Aging Cell 2017
Open access · CC-BY
Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans
Nature Medicine 2024
Preprint · OA
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
Nature Aging 2024
Preprint · OA
Challenges and recommendations for the translation of biomarkers of aging
Mechanisms of Ageing and Development 2021
Preprint · OA
Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions
Molecular Metabolism 2022
Open access · CC-BY
p21 induces a senescence program and skeletal muscle dysfunction
Aging Cell 2023
Open access · CC-BY
Biomarkers of cellular senescence and risk of death in humans
Aging Cell 2021
Open access · CC-BY
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging
American Journal of Respiratory Cell and Molecular Biology 2018
Preprint · OA
Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells
GeroScience 2022
Open access · CC-BY
Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study
bioRxiv (Cold Spring Harbor Laboratory) 2021
Preprint · OA
A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues
EBioMedicine 2020
Open access · CC-BY
Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456
Experimental Gerontology 2016
Preprint · OA
Energetic interventions for healthspan and resiliency with aging
Journal of the American Geriatrics Society 2021
Open access · CC-BY
Fisetin for COVID ‐19 in skilled nursing facilities: Senolytic trials in the COVID era
The Journal of Frailty & Aging 2021
Open access · CC-BY
Identifying Biomarkers for Biological Age: Geroscience and the ICFSR Task Force
Journal of Investigative Dermatology 2022
Open access · OA
Senescent Cells Accumulate in Systemic Sclerosis Skin
Nature Aging 2024
Open access · CC-BY
IL-23R is a senescence-linked circulating and tissue biomarker of aging
Nature Aging 2023
Preprint · OA
Looking at frailty and intrinsic capacity through a geroscience lens: the ICFSR & Geroscience Task Force
bioRxiv (Cold Spring Harbor Laboratory) 2023
Preprint · CC-BY
Distinct secretomes in p16- and p21- positive senescent cells across tissues
The Journals of Gerontology Series A 2023
Preprint · OA
Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial
Aging Cell 2019
Open access · CC-BY
Late‐life time‐restricted feeding and exercise differentially alter healthspan in obesity
Aging Cell 2025
Open access · CC-BY
Characterization of Human Senescent Cell Biomarkers for Clinical Trials
The Journals of Gerontology Series A 2023
Preprint · OA
Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins Follistatin and Follistatin-Like Protein-3 With Dementia and Cognition
The Journals of Gerontology Series A 2023
Preprint · OA
Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins, Follistatin and Follistatin-Like Protein-3, With Measures of Skeletal Muscle Mass, Muscle Strength, and Physical Function in Older Adults
Aging Cell 2024
Open access · CC-BY
Hungry for biomarkers of aging
EMBO Molecular Medicine 2026
Open access · CC-BY
Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice
Research Square 2022
Preprint · CC-BY