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Dietary restriction modulates α‐synuclein expression in the aging rat cortex and hippocampus

Aleksandra Mladenović, Milka Perović, Nikola Tanić, Suzana S. Petanceska, Sabera Ruždijić, Selma Kanazir

Synapse · 2007 · ▲ 19 citations

Loss of proteostasis Caloric restriction Rat

Abstract

Dietary restriction (DR) is one of the promising environmental interventions known to attenuate aging and decrease risk of age-related neurodegenerative disorders. The aim of this study was to assess the effects of DR on expression of alpha-synuclein, a presynaptic protein involved in pathogenesis of Parkinson's and some other neurodegenerative diseases, in the cortex and hippocampus of adult, middle-aged, late middle-aged, and aged rats. Using Real Time RT-PCR, the authors report that aging regulates the expression of alpha-synuclein in a tissue-specific manner and that long-term DR reverts the late age-related changes of alpha-synuclein expression.

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Provenance

Source: OpenAlex
DOI: 10.1002/syn.20427
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Fetched: 2026-10-21 MST

Cite this

APA

Mladenović, A., Perović, M., Tanić, N., Petanceska, S.S., Ruždijić, S., & Kanazir, S. (2007). Dietary restriction modulates α‐synuclein expression in the aging rat cortex and hippocampus. <em>Synapse</em>. https://doi.org/10.1002/syn.20427

Vancouver

Mladenović A, Perović M, Tanić N, Petanceska SS, Ruždijić S, Kanazir S. Dietary restriction modulates α‐synuclein expression in the aging rat cortex and hippocampus. Synapse. 2007. doi:10.1002/syn.20427.

BibTeX

@article{aleksandra2007Dietar, title = {Dietary restriction modulates α‐synuclein expression in the aging rat cortex and hippocampus}, author = {Aleksandra Mladenović and Milka Perović and Nikola Tanić and Suzana S. Petanceska and Sabera Ruždijić and Selma Kanazir}, journal = {Synapse}, year = {2007}, doi = {10.1002/syn.20427}, }