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Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia

Lee Sooyeon, Kristina L. Go, Jae‐Sung Kim

Molecular & Cellular Oncology · 2015 · ▲ 21 citations

Deregulated nutrient-sensing Mitochondrial dysfunction Disabled macroautophagy

Abstract

Sirtuin-1 (SIRT1) is associated with longevity and cell survival. Recently, we unveiled a new role of SIRT1 in hepatic ischemia/reperfusion (I/R) injury and identified a novel interaction between SIRT1 and mitochondrial outer membrane protein mitofusin-2 (MFN2), in which SIRT1-dependent deacetylation of MFN2 regulates mitochondria and autophagy in the liver.

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Provenance

Source: OpenAlex
DOI: 10.1080/23723556.2015.1087452
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Fetched: 2026-10-23 MST

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APA

Sooyeon, L., Go, K.L., & Kim, J. (2015). Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia. <em>Molecular & Cellular Oncology</em>. https://doi.org/10.1080/23723556.2015.1087452

Vancouver

Sooyeon L, Go KL, Kim J. Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia. Molecular & Cellular Oncology. 2015. doi:10.1080/23723556.2015.1087452.

BibTeX

@article{lee2015Deacet, title = {Deacetylation of mitofusin-2 by sirtuin-1: A critical event in cell survival after ischemia}, author = {Lee Sooyeon and Kristina L. Go and Jae‐Sung Kim}, journal = {Molecular & Cellular Oncology}, year = {2015}, doi = {10.1080/23723556.2015.1087452}, }