Contribution of cellular senescence to kidney disease pathogenesis

Cellular senescence(definition) is a crucial process in aging and the pathogenesis of numerous diseases, including kidney diseases. As the kidney ages, the accumulation of senescent cells in renal tissues contributes to the progression of renal diseases such as chronic kidney disease (CKD) and fibrosis. Characterized by irreversible cell cycle arrest, these senescent cells secrete pro-inflammatory cytokines and extracellular matrix components through the senescence-associated secretory phenotype (SASP). This review investigates the molecular mechanisms underlying cellular senescence in the kidney, its impact on renal function, and its role in the development of renal pathologies. Understanding the interplay between aging and the development of renal disease offers valuable insights for the development of therapeutic strategies to slow or reverse renal aging and improve renal health.