Open access · OA via Europe PMC

Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity.

Guo T, Chen Y, Yu Y, Shao Y, Wang C, Zhang H, Xu C, Cheung Y, Chen F, Xu T, Li X, Duan C.

Frontiers in microbiology · 2026

Dysbiosis Human Review

Abstract

The oral-systemic connection, salivary microbiome, and healthy longevity are increasingly recognized as biologically interconnected. This review summarizes lifespan changes in the salivary microbiome, its links to age-related systemic diseases, and recent progress in salivary MicroAge modeling. It further highlights advances in data preprocessing, feature engineering, and artificial intelligence-based prediction, while emphasizing the importance of standardization, generalizability, and biological interpretability for clinical translation. Overall, salivary MicroAge may provide a noninvasive and interpretable framework for biological aging assessment and healthier aging.

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Provenance

Source: Europe PMC
DOI: 10.3389/fmicb.2026.1903972
Canonical: link ↗
Fetched: 2026-10-07 MST

Cite this

APA

T, G., Y, C., Y, Y., Y, S., C, W., H, Z., C, X., Y, C., F, C., T, X., X, L., & C., D. (2026). Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity. <em>Frontiers in microbiology</em>. https://doi.org/10.3389/fmicb.2026.1903972

Vancouver

T G, Y C, Y Y, Y S, C W, H Z, et al. Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity. Frontiers in microbiology. 2026. doi:10.3389/fmicb.2026.1903972.

BibTeX

@article{guo2026Clinic, title = {Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity.}, author = {Guo T and Chen Y and Yu Y and Shao Y and Wang C and Zhang H and Xu C and Cheung Y and Chen F and Xu T and Li X and Duan C.}, journal = {Frontiers in microbiology}, year = {2026}, doi = {10.3389/fmicb.2026.1903972}, }