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Challenges in developing Geroscience trials

Yves Rolland, Felipe Sierra, Luigi Ferrucci, Nir Barzilai, Rafael de Cabo, Joan B. Mannick, Anthony A. Oliva, William J. Evans, Davide Angioni, Philipe de Souto Barreto, Jérémy Raffin, Bruno J. Vellas, James L. Kirkland, the G.C.T-TF group, Sandrine Andrieu

Nature Communications · 2023 · ▲ 94 citations

Dysbiosis Human

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Abstract

Geroscience is becoming a major hope for preventing age-related diseases and loss of function by targeting biological mechanisms of aging. This unprecedented paradigm shift requires optimizing the design of future clinical studies related to aging in humans. Researchers will face a number of challenges, including ideal populations to study, which lifestyle and Gerotherapeutic interventions to test initially, selecting key primary and secondary outcomes of such clinical trials, and which age-related biomarkers are most valuable for both selecting interventions and predicting or monitoring clinical responses ("Gerodiagnostics"). This article reports the main results of a Task Force of experts in Geroscience.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41467-023-39786-7
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Fetched: 2026-11-05 MST

Cite this

APA

Rolland, Y., Sierra, F., Ferrucci, L., Barzilai, N., Cabo, R.D., Mannick, J.B., Oliva, A.A., Evans, W.J., Angioni, D., Barreto, P.D.S., Raffin, J., Vellas, B.J., Kirkland, J.L., group, T.G., Andrieu, S., Bacqueville, D., Bischoff-Ferrari, H.A., Blivet, G., Cash, T.P., & Cuervo, A.M. (2023). Challenges in developing Geroscience trials. <em>Nature Communications</em>. https://doi.org/10.1038/s41467-023-39786-7

Vancouver

Rolland Y, Sierra F, Ferrucci L, Barzilai N, Cabo RD, Mannick JB, et al. Challenges in developing Geroscience trials. Nature Communications. 2023. doi:10.1038/s41467-023-39786-7.

BibTeX

@article{yves2023Challe, title = {Challenges in developing Geroscience trials}, author = {Yves Rolland and Felipe Sierra and Luigi Ferrucci and Nir Barzilai and Rafael de Cabo and Joan B. Mannick and Anthony A. Oliva and William J. Evans and Davide Angioni and Philipe de Souto Barreto and Jérémy Raffin and Bruno J. Vellas and James L. Kirkland and the G.C.T-TF group and Sandrine Andrieu and Daniel Bacqueville and Heike Annette Bischoff-Ferrari and Guillaume Blivet and Timothy P. Cash and Ana María Cuervo and Noélie Davezac and Andrea Dimet‐Wiley and Alexander Fleming and Gérard Friedlander and Mitzi M. Gonzales}, journal = {Nature Communications}, year = {2023}, doi = {10.1038/s41467-023-39786-7}, }