Author
James L. Kirkland
- Indexed works
- 108
- Total citations
- 35,965
- Active years
- 17
Collaborators
Works in the record
Nature 2011
Preprint · OA
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Journal of Clinical Investigation 2013
Open access · OA
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Nature Communications 2017
Open access · CC-BY
Cellular senescence mediates fibrotic pulmonary disease
EBioMedicine 2019
Open access · CC-BY
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Journal of Internal Medicine 2020
Open access · CC-BY
Senolytic drugs: from discovery to translation
Nature Reviews Nephrology 2022
Open access · OA
Cellular senescence: the good, the bad and the unknown
Aging Cell 2015
Open access · CC-BY
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Nature Medicine 2017
Preprint · OA
Targeting cellular senescence prevents age-related bone loss in mice
Aging Cell 2010
Open access · OA
Fat tissue, aging, and cellular senescence
Nature Medicine 2022
Open access · OA
Cellular senescence and senolytics: the path to the clinic
Nature Communications 2017
Open access · CC-BY
Cellular senescence drives age-dependent hepatic steatosis
EBioMedicine 2017
Open access · CC-BY
Cellular Senescence: A Translational Perspective
Nature Communications 2022
Open access · CC-BY
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
EBioMedicine 2018
Open access · CC-BY
Fisetin is a senotherapeutic that extends health and lifespan
Proceedings of the National Academy of Sciences 2015
Open access · OA
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
EMBO Reports 2014
Preprint · OA
Senescence and apoptosis: dueling or complementary cell fates?
Aging 2017
Open access · CC-BY
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Aging Cell 2016
Open access · CC-BY
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Nature Communications 2017
Open access · CC-BY
Identification of HSP90 inhibitors as a novel class of senolytics
eLife 2015
Open access · CC-BY
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Journal of Bone and Mineral Research 2016
Preprint · OA
Identification of Senescent Cells in the Bone Microenvironment
Cell Metabolism 2019
Open access · CC-BY
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
Nature Reviews Endocrinology 2020
Preprint · OA
The role of cellular senescence in ageing and endocrine disease
Nature Aging 2021
Open access · OA
Strategies for targeting senescent cells in human disease
Diabetes 2015
Preprint · OA
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
Aging Cell 2021
Open access · CC-BY
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
JNCI Journal of the National Cancer Institute 2021
Open access · CC-BY
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Cell 2024
Open access · CC-BY
Guidelines for minimal information on cellular senescence experimentation in vivo
Diabetologia 2019
Open access · CC-BY
Cellular senescence: at the nexus between ageing and diabetes
Nature Metabolism 2021
Open access · CC-BY
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
The Annual Review of Pharmacology and Toxicology 2020
Open access · OA
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Experimental Gerontology 2016
Open access · CC-BY
Aging and adipose tissue: potential interventions for diabetes and regenerative medicine
Aging Cell 2019
Open access · CC-BY
Aged‐senescent cells contribute to impaired heart regeneration
EBioMedicine 2023
Open access · CC-BY
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability
Current Opinion in Clinical Nutrition & Metabolic Care 2014
Citation only
Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
Nature Medicine 2023
Preprint · OA
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
Physiology 2016
Preprint · OA
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
Diabetes 2016
Preprint · OA
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
The Journals of Gerontology Series A 2021
Preprint · OA
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice
Nature Communications 2020
Open access · CC-BY
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
The Journal of Prevention of Alzheimer s Disease 2021
Open access · CC-BY
Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial
Trends in Molecular Medicine 2020
Preprint · OA
Reducing Senescent Cell Burden in Aging and Disease
Frontiers in Cell and Developmental Biology 2020
Open access · CC-BY
Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells
FEBS Journal 2020
Open access · CC-BY
Discovery, development, and future application of senolytics: theories and predictions
Nestlé Nutrition Institute Workshop series 2015
Preprint · OA
Cellular Senescence and the Biology of Aging, Disease, and Frailty
Nature reviews. Immunology 2022
Open access · OA
COVID-19 and cellular senescence
Journal of Bone and Mineral Research 2020
Open access · OA
Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss
The Journals of Gerontology Series A 2016
Open access · CC-BY
Strategies and Challenges in Clinical Trials Targeting Human Aging
Biochemical and Biophysical Research Communications 2019
Open access · CC-BY
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Advanced Science 2020
Open access · CC-BY