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Cell size is a determinant of stem cell potential during aging

Jette Lengefeld, Chia‐Wei Cheng, Pema Maretich, Marguerite Blair, Hannah R. Hagen, Melanie R. McReynolds, Emily J. Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim David Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison

bioRxiv (Cold Spring Harbor Laboratory) · 2020 · ▲ 12 citations

Stem-cell exhaustion Human Mouse

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Abstract

Abstract Stem cells are remarkably small in size. Whether small size is important for stem cell function is unknown. We find that murine hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of large HSCs is due to reduced proliferative potential. Preventing HSC enlargement by inhibiting macromolecule biosynthesis or reducing large HSCs size by shortening G 1 averts the loss of stem cell potential under conditions causing stem cell exhaustion. Finally, we show that a fraction of murine and human HSCs enlarge during aging. Preventing this age-dependent enlargement improves HSC function. We conclude that small cell size is important for stem cell function in vivo and propose that stem cell enlargement contributes to their functional decline during aging. One Sentence Summary Size increase drives stem cell aging.

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Provenance

Source: OpenAlex
DOI: 10.1101/2020.10.27.355388
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Fetched: 2026-10-28 MST

Cite this

APA

Lengefeld, J., Cheng, C., Maretich, P., Blair, M., Hagen, H.R., McReynolds, M.R., Sullivan, E.J., Majors, K., Roberts, C., Kang, J.H., Steiner, J.D., Miettinen, T.P., Manalis, S.R., Antebi, A., Morrison, S.J., Lees, J.A., Boyer, L.A., Yilmaz, �.H., & Amon, A. (2020). Cell size is a determinant of stem cell potential during aging. <em>bioRxiv (Cold Spring Harbor Laboratory)</em>. https://doi.org/10.1101/2020.10.27.355388

Vancouver

Lengefeld J, Cheng C, Maretich P, Blair M, Hagen HR, McReynolds MR, et al. Cell size is a determinant of stem cell potential during aging. bioRxiv (Cold Spring Harbor Laboratory). 2020. doi:10.1101/2020.10.27.355388.

BibTeX

@unpublished{jette2020Cellsi, title = {Cell size is a determinant of stem cell potential during aging}, author = {Jette Lengefeld and Chia‐Wei Cheng and Pema Maretich and Marguerite Blair and Hannah R. Hagen and Melanie R. McReynolds and Emily J. Sullivan and Kyra Majors and Christina Roberts and Joon Ho Kang and Joachim David Steiner and Teemu P. Miettinen and Scott R. Manalis and Adam Antebi and Sean J. Morrison and Jacqueline A. Lees and Laurie A. Boyer and Ömer H. Yilmaz and Angelika Amon}, journal = {bioRxiv (Cold Spring Harbor Laboratory)}, year = {2020}, doi = {10.1101/2020.10.27.355388}, }