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Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling

Li Li, Bing Wang, Yawei Li, Lei Li, Yuliang Dai, Guohua Lv, Pengfei Wu, Pengzhi Li

Aging · 2020 · ▲ 17 citations

Stem-cell exhaustion Altered intercellular communication Stem-cell therapy Mouse

Abstract

. Mechanistically, Celastrol was able to control the differentiation of BM-MSCs by stimulating PGC-1α signaling. Moreover, administration of Celastrol could alleviate bone loss and bone marrow adipose tissue (MAT) accumulation in ovariectomized (OVX) mice and aged mice. Together, these results recommended that Celastrol could regulate BM-MSCs fate and bone-fat balance in OP and skeletal aging by stimulating PGC-1α, which might act as a possible therapeutic target for OP and for the prevention of skeletal aging.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.103590
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Fetched: 2026-10-18 MST

Cite this

APA

Li, L., Wang, B., Li, Y., Li, L., Dai, Y., Lv, G., Wu, P., & Li, P. (2020). Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling. <em>Aging</em>. https://doi.org/10.18632/aging.103590

Vancouver

Li L, Wang B, Li Y, Li L, Dai Y, Lv G, et al. Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling. Aging. 2020. doi:10.18632/aging.103590.

BibTeX

@article{li2020Celast, title = {Celastrol regulates bone marrow mesenchymal stem cell fate and bone-fat balance in osteoporosis and skeletal aging by inducing PGC-1α signaling}, author = {Li Li and Bing Wang and Yawei Li and Lei Li and Yuliang Dai and Guohua Lv and Pengfei Wu and Pengzhi Li}, journal = {Aging}, year = {2020}, doi = {10.18632/aging.103590}, }