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Autophagy Regulates Ageing in<i>C. elegans</i>

Eszter S. Hars, Haiyan Qi, Shengkan V. Jin, Li Cai, Chengcheng Hu, Leroy F. Liu

Autophagy · 2007 · ▲ 240 citations

Disabled macroautophagy Yeast C. elegans
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Abstract

The role of autophagy(definition) in ageing regulation has been suggested based on studies in C. elegans, in which knockdown of the expression of bec-1 (ortholog of the yeast and mammalian autophagy genes ATG6/VPS30 and beclin 1, respectively) shortens lifespan of the daf-2(e1370) mutant C. elegans. However, Beclin1/ATG6 is also known to be involved in other cellular functions in addition to autophagy. In the current study, we knocked down two other autophagy genes, atg-7 and atg-12, in C. elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation.

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Provenance

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OpenAlex
DOI
10.4161/auto.3636
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2026-08-07 MST

Cite this

APA
Hars, E.S., Qi, H., Jin, S.V., Cai, L., Hu, C., &amp; Liu, L.F. (2007). Autophagy Regulates Ageing in<i>C. elegans</i>. <em>Autophagy</em>. https://doi.org/10.4161/auto.3636
Vancouver
Hars ES, Qi H, Jin SV, Cai L, Hu C, Liu LF. Autophagy Regulates Ageing in<i>C. elegans</i>. Autophagy. 2007. doi:10.4161/auto.3636.
BibTeX
@article{eszter2007Autoph, title = {Autophagy Regulates Ageing in<i>C. elegans</i>}, author = {Eszter S. Hars and Haiyan Qi and Shengkan V. Jin and Li Cai and Chengcheng Hu and Leroy F. Liu}, journal = {Autophagy}, year = {2007}, doi = {10.4161/auto.3636}, }

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