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An older subjective age is related to accelerated epigenetic aging.

Yannick Stéphan, Angelina R. Sutin, Martina Luchetti, Antonio Terracciano

Psychology and Aging · 2021 · ▲ 39 citations

Epigenetic alterations Chronic inflammation

Abstract

The present study examined the prospective association between subjective age and epigenetic clock in 2,253 adults (Mean age = 67.40, SD = 8.17) from the Health and Retirement Study. Subjective age and demographic factors were assessed in 2008/2010 and epigenetic clock was assessed in 2016 using the DNA methylation (DNAm) PhenoAge. Regression analysis revealed that an older subjective age was associated with accelerated epigenetic aging; mediation analysis revealed that self-rated health and CRP accounted for this association. The findings indicate that individuals who feel older than their chronological age are biologically older, in part because of their perceived health and inflammatory profiles. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

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Provenance

Source: OpenAlex
DOI: 10.1037/pag0000607
Canonical: link ↗
Fetched: 2026-07-22 MST

Cite this

APA

Stéphan, Y., Sutin, A.R., Luchetti, M., & Terracciano, A. (2021). An older subjective age is related to accelerated epigenetic aging. <em>Psychology and Aging</em>. https://doi.org/10.1037/pag0000607

Vancouver

Stéphan Y, Sutin AR, Luchetti M, Terracciano A. An older subjective age is related to accelerated epigenetic aging. Psychology and Aging. 2021. doi:10.1037/pag0000607.

BibTeX

@article{yannick2021Anolde, title = {An older subjective age is related to accelerated epigenetic aging.}, author = {Yannick Stéphan and Angelina R. Sutin and Martina Luchetti and Antonio Terracciano}, journal = {Psychology and Aging}, year = {2021}, doi = {10.1037/pag0000607}, }