Open access · CC-BY via OpenAlex

Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks

Daniel Kurbanov, Farida Ahangari, Taylor Sterling Adams, Ruben De Man, Jessica Tang, Marianne Sylvia Carlon, Nebal S. Abu Hussein, Emanuela Elsa Cortesi, Marta Zapata, Laurens De Sadeleer, Wim A Wuyts, Bart M. Vanaudenaerde, Naftali Kaminski, John E. McDonough

American Journal of Physiology-Lung Cellular and Molecular Physiology · 2025 · ▲ 12 citations

Epigenetic alterations

＋ Sign in to save

Abstract

Using epigenetic clocks, we found a notable acceleration of biological aging in IPF tissues, particularly in DunedinPACE, suggesting that the biological aging process in IPF is accelerated and closely related to the severity of the disease. The study also underscores DNA methylation's potential as a biomarker for IPF, as well as the dynamics of epigenetic aging and the need to consider biological age in medical research and healthcare.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1152/ajplung.00171.2024
Canonical: link ↗
Fetched: 2026-10-14 MST

Cite this

APA

Kurbanov, D., Ahangari, F., Adams, T.S., Man, R.D., Tang, J., Carlon, M.S., Hussein, N.S.A., Cortesi, E.E., Zapata, M., Sadeleer, L.D., Wuyts, W.A., Vanaudenaerde, B.M., Kaminski, N., & McDonough, J.E. (2025). Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks. <em>American Journal of Physiology-Lung Cellular and Molecular Physiology</em>. https://doi.org/10.1152/ajplung.00171.2024

Vancouver

Kurbanov D, Ahangari F, Adams TS, Man RD, Tang J, Carlon MS, et al. Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks. American Journal of Physiology-Lung Cellular and Molecular Physiology. 2025. doi:10.1152/ajplung.00171.2024.

BibTeX

@article{daniel2025Epigen, title = {Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks}, author = {Daniel Kurbanov and Farida Ahangari and Taylor Sterling Adams and Ruben De Man and Jessica Tang and Marianne Sylvia Carlon and Nebal S. Abu Hussein and Emanuela Elsa Cortesi and Marta Zapata and Laurens De Sadeleer and Wim A Wuyts and Bart M. Vanaudenaerde and Naftali Kaminski and John E. McDonough}, journal = {American Journal of Physiology-Lung Cellular and Molecular Physiology}, year = {2025}, doi = {10.1152/ajplung.00171.2024}, }