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Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions

Xiao Dong, Shixiang Sun, Lei Zhang, Seungsoo Kim, Zhidong Tu, Cristina Montagna, Alexander Y. Maslov, Yousin Suh, Tao Wang, Judith Campisi, Jan Vijg

Aging Cell · 2021 · ▲ 20 citations

Telomere attrition Cellular senescence Human

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Abstract

Telomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging.

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Provenance

Source: OpenAlex
DOI: 10.1111/acel.13357
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Fetched: 2026-07-18 MST

Cite this

APA

Dong, X., Sun, S., Zhang, L., Kim, S., Tu, Z., Montagna, C., Maslov, A.Y., Suh, Y., Wang, T., Campisi, J., & Vijg, J. (2021). Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions. <em>Aging Cell</em>. https://doi.org/10.1111/acel.13357

Vancouver

Dong X, Sun S, Zhang L, Kim S, Tu Z, Montagna C, et al. Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions. Aging Cell. 2021. doi:10.1111/acel.13357.

BibTeX

@article{xiao2021Agerel, title = {Age‐related telomere attrition causes aberrant gene expression in sub‐telomeric regions}, author = {Xiao Dong and Shixiang Sun and Lei Zhang and Seungsoo Kim and Zhidong Tu and Cristina Montagna and Alexander Y. Maslov and Yousin Suh and Tao Wang and Judith Campisi and Jan Vijg}, journal = {Aging Cell}, year = {2021}, doi = {10.1111/acel.13357}, }