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Aged murine hematopoietic stem cells drive aging-associated immune remodeling

Hanna Leins, Medhanie Mulaw, Karina Eiwen, Vadim Sakk, Ying Liang, Michael Denkinger, Hartmut Geiger, Reinhold Schirmbeck

Blood · 2018 · ▲ 102 citations

Epigenetic alterations Stem-cell exhaustion Mouse

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Abstract

hosts that mirrored young and aged immune systems. Importantly, aged HSCs treated with CASIN reestablished an immune system similar to that of young animals, and thus capable of mounting a strong immune response to vaccination. Our studies further imply that epigenetic signatures already imprinted in aged HSCs determine the transcriptional profile and function of HSC-derived T and B cells.

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Provenance

Source: OpenAlex
DOI: 10.1182/blood-2018-02-831065
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Fetched: 2026-07-14 MST

Cite this

APA

Leins, H., Mulaw, M., Eiwen, K., Sakk, V., Liang, Y., Denkinger, M., Geiger, H., & Schirmbeck, R. (2018). Aged murine hematopoietic stem cells drive aging-associated immune remodeling. <em>Blood</em>. https://doi.org/10.1182/blood-2018-02-831065

Vancouver

Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, et al. Aged murine hematopoietic stem cells drive aging-associated immune remodeling. Blood. 2018. doi:10.1182/blood-2018-02-831065.

BibTeX

@article{hanna2018Agedmu, title = {Aged murine hematopoietic stem cells drive aging-associated immune remodeling}, author = {Hanna Leins and Medhanie Mulaw and Karina Eiwen and Vadim Sakk and Ying Liang and Michael Denkinger and Hartmut Geiger and Reinhold Schirmbeck}, journal = {Blood}, year = {2018}, doi = {10.1182/blood-2018-02-831065}, }