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Additional file 2 of Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans

Yi‐Cheng Lin, Yun-Hsun Liao, Sin-Bo Liao, Tzu-Yu Lin, Muniesh Muthaiyan Shanmugam, P. J. Hsu, Chang‐Shi Chen, Tsui‐Ting Ching, Oliver Ingvar Wagner, Chiou‐Hwa Yuh, Horng‐Dar Wang

Figshare · 2026

Deregulated nutrient-sensing Altered intercellular communication C. elegans Human

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Abstract

Supplementary material 2. Supplementary Fig. 2. GEO shows reduced class II PITP expression in old age. (A) Whole-genome microarray data from C. elegans [39] revealed significant reductions in both pitp-1 splice variants at day-6 and day-15 adults compared to L4 larvae (One-way ANOVA). (B-G) Microarray analysis of human frontal cortex [40] showed that expression of PITPNM2 (232950_at) and PITPNM3 (230076_at) was significantly lower in individuals > 90 years (extremely old) compared to those < 40 years (young) in both sexes, while PITPNM1 showed a slight, non-significant decrease (unpaired Student’s t-test).

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Provenance

Source: OpenAlex
DOI: 10.6084/m9.figshare.32109948
Canonical: link ↗
Fetched: 2026-10-22 MST

Cite this

APA

Lin, Y., Liao, Y., Liao, S., Lin, T., Shanmugam, M.M., Hsu, P.J., Chen, C., Ching, T., Wagner, O.I., Yuh, C., & Wang, H. (2026). Additional file 2 of Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans. <em>Figshare</em>. https://doi.org/10.6084/m9.figshare.32109948

Vancouver

Lin Y, Liao Y, Liao S, Lin T, Shanmugam MM, Hsu PJ, et al. Additional file 2 of Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans. Figshare. 2026. doi:10.6084/m9.figshare.32109948.

BibTeX

@unpublished{yicheng2026Additi, title = {Additional file 2 of Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans}, author = {Yi‐Cheng Lin and Yun-Hsun Liao and Sin-Bo Liao and Tzu-Yu Lin and Muniesh Muthaiyan Shanmugam and P. J. Hsu and Chang‐Shi Chen and Tsui‐Ting Ching and Oliver Ingvar Wagner and Chiou‐Hwa Yuh and Horng‐Dar Wang}, journal = {Figshare}, year = {2026}, doi = {10.6084/m9.figshare.32109948}, }