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α-Klotho as a Regulator of Calcium Homeostasis

Akihiro Imura, Yoshihito Tsuji, Miyahiko Murata, Ryota Maeda, Koji Kubota, Akiko Iwano, Chikashi Obuse, Kazuya Togashi, Makoto Tominaga, Naoko Kita, Ken-ichi Tomiyama, Junko Iijima, Yoko Nabeshima, Makio Fujioka, Ryo Asato

Science · 2007 · ▲ 385 citations

Deregulated nutrient-sensing Mouse

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Abstract

alpha-klotho was identified as a gene associated with premature aging-like phenotypes characterized by short lifespan. In mice, we found the molecular association of alpha-Klotho (alpha-Kl) and Na+,K+-adenosine triphosphatase (Na+,K+-ATPase) and provide evidence for an increase of abundance of Na+,K+-ATPase at the plasma membrane. Low concentrations of extracellular free calcium ([Ca2+]e) rapidly induce regulated parathyroid hormone (PTH) secretion in an alpha-Kl- and Na+,K+-ATPase-dependent manner. The increased Na+ gradient created by Na+,K+-ATPase activity might drive the transepithelial transport of Ca2+ in cooperation with ion channels and transporters in the choroid plexus and the kidney. Our findings reveal fundamental roles of alpha-Kl in the regulation of calcium metabolism.

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Provenance

Source: OpenAlex
DOI: 10.1126/science.1135901
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Fetched: 2026-10-26 MST

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APA

Imura, A., Tsuji, Y., Murata, M., Maeda, R., Kubota, K., Iwano, A., Obuse, C., Togashi, K., Tominaga, M., Kita, N., Tomiyama, K., Iijima, J., Nabeshima, Y., Fujioka, M., Asato, R., Tanaka, S., Kojima, K., Ito, J., Nozaki, K., & Hashimoto, N. (2007). α-Klotho as a Regulator of Calcium Homeostasis. <em>Science</em>. https://doi.org/10.1126/science.1135901

Vancouver

Imura A, Tsuji Y, Murata M, Maeda R, Kubota K, Iwano A, et al. α-Klotho as a Regulator of Calcium Homeostasis. Science. 2007. doi:10.1126/science.1135901.

BibTeX

@article{akihiro2007Klotho, title = {α-Klotho as a Regulator of Calcium Homeostasis}, author = {Akihiro Imura and Yoshihito Tsuji and Miyahiko Murata and Ryota Maeda and Koji Kubota and Akiko Iwano and Chikashi Obuse and Kazuya Togashi and Makoto Tominaga and Naoko Kita and Ken-ichi Tomiyama and Junko Iijima and Yoko Nabeshima and Makio Fujioka and Ryo Asato and Shinzo Tanaka and Ken Kojima and Juichi Ito and Kazuhiko Nozaki and Nobuo Hashimoto and Tetsufumi Ito and Takeshi Nishio and Takashi Uchiyama and Toshihiko Fujimori}, journal = {Science}, year = {2007}, doi = {10.1126/science.1135901}, }