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A Developmental Timing MicroRNA and Its Target Regulate Life Span in <i>C. elegans</i>

Michelle Boehm, Frank J. Slack

Science · 2005 · ▲ 443 citations

Deregulated nutrient-sensing C. elegans
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Abstract

The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Lifespan extension conferred by a reduction in lin-14 was dependent on the DAF-16 and HSF-1 transcription factors, suggesting that the lin-4-lin-14 pair affects life span through the insulin/insulin-like growth factor-1 pathway. This work reveals a role for microRNAs and developmental timing genes in life-span regulation.

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Provenance

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OpenAlex
DOI
10.1126/science.1115596
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2026-07-22 MST

Cite this

APA
Boehm, M., &amp; Slack, F.J. (2005). A Developmental Timing MicroRNA and Its Target Regulate Life Span in <i>C. elegans</i>. <em>Science</em>. https://doi.org/10.1126/science.1115596
Vancouver
Boehm M, Slack FJ. A Developmental Timing MicroRNA and Its Target Regulate Life Span in <i>C. elegans</i>. Science. 2005. doi:10.1126/science.1115596.
BibTeX
@article{michelle2005ADevel, title = {A Developmental Timing MicroRNA and Its Target Regulate Life Span in <i>C. elegans</i>}, author = {Michelle Boehm and Frank J. Slack}, journal = {Science}, year = {2005}, doi = {10.1126/science.1115596}, }

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