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A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

Yang Yang, Natacha Jn-Simon, Yonghan He, Chunbao Sun, Peiyi Zhang, Wanyi Hu, Tian Tian, Huadong Zeng, Sreenivasulu Basha, Araceli S. Huerta, Lu‐Zhe Sun, Xiao‐Ming Yin, Robert Hromas, Guangrong Zheng, Liya Pi

Nature Aging · 2025 · ▲ 42 citations

Cellular senescence Mouse

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Provenance

Source: OpenAlex
DOI: 10.1038/s43587-025-00811-7
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Fetched: 2026-06-19 MST

Cite this

APA

Yang, Y., Jn-Simon, N., He, Y., Sun, C., Zhang, P., Hu, W., Tian, T., Zeng, H., Basha, S., Huerta, A.S., Sun, L., Yin, X., Hromas, R., Zheng, G., Pi, L., & Zhou, D. (2025). A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice. <em>Nature Aging</em>. https://doi.org/10.1038/s43587-025-00811-7

Vancouver

Yang Y, Jn-Simon N, He Y, Sun C, Zhang P, Hu W, et al. A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice. Nature Aging. 2025. doi:10.1038/s43587-025-00811-7.

BibTeX

@unpublished{yang2025ABCLxL, title = {A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice}, author = {Yang Yang and Natacha Jn-Simon and Yonghan He and Chunbao Sun and Peiyi Zhang and Wanyi Hu and Tian Tian and Huadong Zeng and Sreenivasulu Basha and Araceli S. Huerta and Lu‐Zhe Sun and Xiao‐Ming Yin and Robert Hromas and Guangrong Zheng and Liya Pi and Daohong Zhou}, journal = {Nature Aging}, year = {2025}, doi = {10.1038/s43587-025-00811-7}, }