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Evidence brief · intervention

Telomerase activation

Synthesized from 10 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Building roots in a changing environment: implications for root longevity
  2. [2] Mutations in <i>TERT,</i> the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia
  3. [3] Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
  4. [4] Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
  5. [5] Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
  6. [6] Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration
  7. [7] Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells
  8. [8] Mechanisms of Molecular Mimicry Involving the Microbiota in Neurodegeneration
  9. [9] Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis
  10. [10] Microbiome-based therapeutics towards healthier aging and longevity.
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