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Evidence brief · intervention

Plasma dilution / young plasma

Synthesized from 10 indexed sources · 2026-06-29 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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  1. [1] Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle
  2. [2] Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain
  3. [3] The ins and outs of muscle stem cell aging
  4. [4] Regulatory T cells and skeletal muscle regeneration
  5. [5] Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice
  6. [6] Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin
  7. [7] Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice
  8. [8] Aging and brain rejuvenation as systemic events
  9. [9] Young blood-induced rejuvenation of neurovascular coupling involves endothelial IGF-1/IGF-1R signaling: evidence from heterochronic parabiosis using endothelial IGF-1R deficient and systemic IGF-1 knockdown mice
  10. [10] Blood as the mirror and modulator of aging: mechanistic insights and rejuvenation strategies
All Plasma dilution / young plasma works → Intervention dossier →