Evidence brief · intervention
Partial reprogramming (OSK)
Synthesized from 10 indexed sources ·
2026-06-03 MST
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
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Sources
- [1] Epigenetics in cancer
- [2] Microglial <scp>M1/M2</scp> polarization and metabolic states
- [3] Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
- [4] Autophagy in major human diseases
- [5] Mechanisms and functions of cellular senescence
- [6] Senescence-associated reprogramming promotes cancer stemness
- [7] Role of cardiolipin alterations in mitochondrial dysfunction and disease
- [8] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
- [9] Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions.
- [10] Fanconi anaemia as a human model of accelerated epigenetic and immune ageing.