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Autophagy in major human diseases

Daniel J. Klionsky, Giulia Petroni, Ravi K. Amaravadi, Eric H. Baehrecke, Andrea Ballabio, Patricia Boya, José Manuel Bravo‐San Pedro, Ken Cadwell, Francesco Cecconi, Augustine M.K. Choi, Mary E. Choi, Charleen T. Chu, Patrice Codogno, María Isabel Colombo, Ana María Cuervo

The EMBO Journal · 2021 · ▲ 1,532 citations

Disabled macroautophagy Partial reprogramming (OSK) Human Preclinical / animal Review

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Abstract

Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.

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Provenance

Source: OpenAlex
DOI: 10.15252/embj.2021108863
Canonical: link ↗
Fetched: 2026-06-04 MST

Cite this

APA

Klionsky, D.J., Petroni, G., Amaravadi, R.K., Baehrecke, E.H., Ballabio, A., Boya, P., Pedro, J.M.B., Cadwell, K., Cecconi, F., Choi, A.M., Choi, M.E., Chu, C.T., Codogno, P., Colombo, M.I., Cuervo, A.M., Deretić, V., Đikić, I., Elazar, Z., Eskelinen, E., & Fimia, G.M. (2021). Autophagy in major human diseases. <em>The EMBO Journal</em>. https://doi.org/10.15252/embj.2021108863

Vancouver

Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, et al. Autophagy in major human diseases. The EMBO Journal. 2021. doi:10.15252/embj.2021108863.

BibTeX

@article{daniel2021Autoph, title = {Autophagy in major human diseases}, author = {Daniel J. Klionsky and Giulia Petroni and Ravi K. Amaravadi and Eric H. Baehrecke and Andrea Ballabio and Patricia Boya and José Manuel Bravo‐San Pedro and Ken Cadwell and Francesco Cecconi and Augustine M.K. Choi and Mary E. Choi and Charleen T. Chu and Patrice Codogno and María Isabel Colombo and Ana María Cuervo and Vojo Deretić and Ivan Đikić and Zvulun Elazar and Eeva‐Liisa Eskelinen and Gian María Fimia and David A. Gewirtz and Douglas R. Green and Malene Hansen and Marja Jäättelä and Terje Johansen}, journal = {The EMBO Journal}, year = {2021}, doi = {10.15252/embj.2021108863}, }