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Evidence brief · intervention

Gene therapy

Synthesized from 10 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
  2. [2] Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
  3. [3] Lysosomal Storage Diseases: From Pathophysiology to Therapy
  4. [4] Glucocerebrosidase and its relevance to Parkinson disease
  5. [5] Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1
  6. [6] Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain
  7. [7] Aberrant Methylation and Deacetylation of <i>Deleted in Liver Cancer-1</i> Gene in Prostate Cancer: Potential Clinical Applications
  8. [8] CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease
  9. [9] CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
  10. [10] Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita
All Gene therapy works → Intervention dossier →