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Evidence brief · intervention

Gene therapy

Synthesized from 10 indexed sources · 2026-07-27 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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  1. [1] Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
  2. [2] Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow
  3. [3] Stem cell-based therapy for human diseases
  4. [4] Endoplasmic reticulum stress: molecular mechanism and therapeutic targets
  5. [5] Aging of mesenchymal stem cell in vitro
  6. [6] Characterization of the Optimal Culture Conditions for Clinical Scale Production of Human Mesenchymal Stem Cells
  7. [7] Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer
  8. [8] Human Endothelial Cell Life Extension by Telomerase Expression
  9. [9] Young blood-induced rejuvenation of neurovascular coupling involves endothelial IGF-1/IGF-1R signaling: evidence from heterochronic parabiosis using endothelial IGF-1R deficient and systemic IGF-1 knockdown mice
  10. [10] A Rras2-BMPR2 feedback loop sustains osteogenesis and represents a therapeutic target for osteoporosis.
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