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Evidence brief · hallmark

Deregulated nutrient-sensing

Synthesized from 10 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Older Adults' Reasons for Using Technology while Aging in Place
  2. [2] The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
  3. [3] Engineering precision nanoparticles for drug delivery
  4. [4] Systematic review of the health benefits of physical activity and fitness in school-aged children and youth
  5. [5] INTCAL98 Radiocarbon Age Calibration, 24,000–0 cal BP
  6. [6] Evidence Based Physical Activity for School-age Youth
  7. [7] Upstream and downstream of mTOR
  8. [8] Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from <i>BRCA</i> Mutation Carriers
  9. [9] SIRT1 in Atherosclerosis: Integrative Control of Vascular Metabolism, Inflammation and Aging.
  10. [10] No evidence lithium supplementation extends lifespan in male Drosophila melanogaster.
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