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Evidence brief · hallmark

Cellular senescence

Synthesized from 10 indexed sources · 2026-06-05 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Aging: A Theory Based on Free Radical and Radiation Chemistry
  2. [2] A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
  3. [3] Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
  4. [4] Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
  5. [5] The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
  6. [6] Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
  7. [7] Leaf Senescence: Correlated with Increased Levels of Membrane Permeability and Lipid Peroxidation, and Decreased Levels of Superoxide Dismutase and Catalase
  8. [8] Cellular senescence: when bad things happen to good cells
  9. [9] Insights into the therapeutic strategies for aging and aging-associated diseases
  10. [10] Reprogramming Skin Aging: A Regenerative and Epigenetic Perspective on Cutaneous Longevity
All Cellular senescence works →